Antinociceptive activity of Buddleja globosa (matico) in several models of pain.
نویسندگان
چکیده
ETHNOPHARMACOLOGICAL RELEVANCE Leaf extracts of Buddleja globosa (Buddlejaceae) are used in Chilean folk medicine for wound healing. The anti-inflammatory (topic and per os), analgesic (per os) effects and the antioxidant activity of Buddleja globosa were for the first time reported by us. AIM OF THE STUDY Assess the antinociceptive activity of the methanol sequential and global extracts using complementary chemical and thermal models of pain, characterize pharmacologically the antinociception induced, evaluate seasonal influence to support Buddleja globosa medicinal use. MATERIALS AND METHODS Global methanol, sequential methanol and ethanol (leaves collected in autumn and summer) extracts were evaluated for oral and topic analgesia in tail flick, formalin and writhing models, verbascoside and 7-O-luteolin glucoside were assayed in tail flick and writhing. Ibuprofen was used as reference. For characterization of induced antinociception, naltrexone, naltrindole, tropisetron, nor-binaltorphimine, prazosin, yohimbine, atropine, and N-nitro-l-arginine methyl ester were used as antagonists and inhibitors drugs. RESULTS Seasonal influence was observed since autumn extract resulted less active. Extracts showed a dose-dependent antinociceptive activity in all assays, the highest effects were obtained for the formalin and writhing test. Verbascoside was more active than ibuprofen in the writhing test (67.6% and 50.0% at equimolar doses) and showed similar effects in the tail flick (topic and oral) near 25% at equivalent doses - ED25 or EC25 - to ibuprofen. Luteolin 7-O-glucoside was slightly more active in the tail flick test and nearly half active than verbascoside in the writhing assay. Effectiveness was higher for the sequential than for global alcoholic extracts, and can be increased by selective blocking of opioid receptors. Global methanol extract seems modulated only by naltrexone. CONCLUSIONS Analgesic effect of Buddleja globosa is here demonstrated validating its use in traditional medicine. Season influence is important to be considered.
منابع مشابه
A study on the site of antinociceptive effect of Trigonella foenum graecum (TFG) leaves extract in phasic and tonic models of pain
There are several reports on the therapeutic effects of TFG in Iranian traditional medical literature such as antinociceptive, antipyretic, and anti-inflammatory, antidiabetic and antidiuretic effects. The anti-inflammatory and anti-pyretic effects of TFG have been confirmed in experimental models. In the present study, the antinociceptive effect of TFG extract in formalin and tail flick test...
متن کاملEvaluation of Antinociceptive Activity of Berberis Vulgaris L. Fruit’s Hydroethanolic Extract in Male Mice
Herbal medicine has an old history with a broad application all over the world. Many researches have focused on the curative as well as antinociceptive effects of herbal extract. The aim of this study was to investigate the analgesic effects of Berberis vulgaris hydroethanolic extract (BVE) in male mice. 30 male mice were divided into 5 groups: control, treated by morphine, treated by ...
متن کاملEvaluation of biological activity of Polygala boliviensis in experimental models
The plants of the genus Polygala (Polygalaceae) are employed in folk medicine for the treatment of several pathologies, including disorders of the bowel and kidney, as anesthetic, expectorant and anti-inflammatory. The present study was undertaken to investigate the antiedematogenic and antinociceptive activities of methanolic extract of Polygala boliviensis A. W. Benn (MEPB) in mice. The antin...
متن کاملA Study of Chemistry and Antinociceptive Properties of Medicinal Plant Allium Jesdianum Leaves and the Probable Role of Opioidergic System
Khaksarian M1, Meshkatosadat MH2, Farzi R3, Safarpour F3 1. Instructor, Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences 2. Associate Professor, Department of Chemistry, Faculty of Basic sciences, Lorestan University 3. M.Sc of Physiology, Staff member of Neurology Sciences Research Center, Kerman University of Medical Sciences Abstract Backgr...
متن کاملThe Ethanolic Extract of Eysenhardtia polystachya (Ort.) Sarg. Bark and Its Fractions Delay the Progression of Rheumatoid Arthritis and Show Antinociceptive Activity in Murine Models
Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesicagent, but no systematic study of its effects on several markers associated with rheumatoidarthritis and its ethnomedical use as analgesic agent has been performed. We evaluated theanti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) barkand its rich-flavonoids frac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of ethnopharmacology
دوره 119 1 شماره
صفحات -
تاریخ انتشار 2008